Testosterone Production

Testosterone Production

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Animation Description: This animation represents a visual interpretation of the production of testosterone and is not indicative of clinical effectiveness.
The hypothalamus releases gonadotropin-releasing hormone (GnRH) in pulses every 60 to 90 minutes to stimulate the pulsatile release of luteinizing hormone (LH) from the pituitary gland into the bloodstream.
LH binds the LH receptor on the Leydig cells of the testes.
Binding initiates a cascade of events which include the conversion of cholesterol (depicted as LDL here) to pregnenolone followed by a series of reactions, which convert pregnenolone to testosterone.
Testosterone, secreted by the testes, diffuses into the peripheral circulation to be carried to target tissues.
In liver, muscle and adipose tissue, testosterone binds directly to its androgen receptor (AR) to exert its biological effect.
In skin, hair, the prostate gland and gonadal tissue, testosterone must be converted to dihydrotestosterone (DHT) by 5-alpha-reductase in order to bind the androgen receptor.
In bone and brain, testosterone is converted by aromatization to estradiol (E2), which binds the estrogen receptor (E2R) to carry out its effects.

There is an accompanying accredited online resource, that contains the learning materials, as well as videos, animations & an interactive algorithm.

Patient Education Video: Low Testosterone

Patient Education Video: Low Testosterone

The New Erectile Dysfunction Formula!

The ALL NATURAL Sex Life Saver Drugs Companies Hope You’ll NEVER DISCOVER!

Man in depressed

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This video, created by Nucleus Medical Media, shows the normal activity of testosterone and treatment for men with abnormally low testosterone levels. Deficiency of this male hormone may result in a condition called androgen deficiency, or hypogonadism, which may include increased body fat, reduced muscle size, and swollen breasts. Testosterone replacement therapy is the administration of man-made testosterone to restore a healthy hormone level in the blood and to relieve symptoms. Treatment options can be in the form of an injection, patch, gel, or tablet.

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